-
Related books
Illegal Drugs: A Complete Guide to their History, Chemistry, Use, and Abuse
by Paul Gahlinger (Paperback - Dec 30, 2003)
Excerpt:
... "366 oxycodone 366 Theboine 366 Tilidine 367 Opioids: Synthetic Narcotics 367 anileridine 367 etorphine 367" ...
More about this bookGoldfrank's Toxicologic Emergencies (Toxicologic Emergencies (Goldfrank's))
by Neal Flomenbaum, Lewis Goldfrank, Robert Hoffman, and Mary Ann Howland (Hardcover - Mar 28, 2006)
Excerpt:
... "J Toxicol Clin Toxicol 1999; sorption of tilidine HCI by activated charcoal. J Toxicol Clin Toxicol 37:833-837. 1986;24:503-517." ...
More about this bookGlobal Drug Enforcement: Practical Investigative Techniques (Practical Aspects of Criminal & Forensic Investigations)
by Gregory D. Lee (Hardcover - Oct 27, 2003)
Excerpt:
... "Thebacetyl Thiofentanyl 9835 Chine white, fentanyl Tilidine 9750 Tilidate, Valoron, Kitadol, Lak," ...
More about this bookLegally Stoned: 14 Mind-Altering Substances You Can Obtain and Use Without Breaking the Law
by Todd A. Thies (Paperback - Jan 1, 2009)
Excerpt:
... "thebacon [Acetylhydrocodone, Acedicon, Thebacetyl] thiofentanyl [Chine white, fentanyl] tilidine [Tilidate, Valoron," ...
More about this bookDrugs During Pregnancy and Lactation, Second Edition: Treatment Options and Risk Assessment (Schaefer, Drugs During Pregnancy and Lactation)
by Christof Schaefer, Paul W.J. Peters, and Richard K Miller (Hardcover - Jul 31, 2007)
Excerpt:
... "be reckoned with. pentazocine can enhance uterine contractility. Pentazocine, like tilidine, has been unable to establish itself as a substitute for" ...
More about this bookTumescent Local Anesthesia
by C.W. Hanke, B. Sommer, and G. Sattler (Hardcover - Jan 25, 2001)
Excerpt:
... "substance diazepam diazepam midazolam midazolam midazolam triazolam paracetamol metamizole tramadol Tilidine" ...
More about this bookAnalytical and Practical Aspects of Drug Testing in Hair (International Forensic Science and Investigation)
by Pascal Kintz (Hardcover - Aug 30, 2006)
Excerpt:
... "buffer L/L LC-MS n I III) three segments 5.07-7.06 water/acetone Tilidine 13-glucuronidase SPE GC/MS n = I arylsulfatase Segment 0-3 cm:" ...
More about this bookEMS Medication Field Guide, Fourth Edition
by Peter Dillman (Spiral-bound - Nov 25, 2004)
Excerpt:
... "ketobemidone, LSD, marijuana, MDA, mescaline, methaqualone, peyote, psilocybin, THC, and tilidine." ...
More about this bookDermatological and Transdermal Formulations (Drugs and the Pharmaceutical Sciences)
by Kenneth A. Walters (Hardcover - Feb 20, 2002)
Excerpt:
... "(48%), immediate-release morphine (17%), buprenorphine (11%), tramadol (11%), levomethadone (5%), tilidine/naloxone (5%), and piritramid (3%)." ...
More about this bookPoisoning and Toxicology Handbook, Fourth Edition (Poisoning and Toxicology Handbook (Leiken & Paloucek's))
by Jerrold B. Leikin and Frank P. Paloucek (Hardcover - Aug 10, 2007)
Excerpt:
... "K, et al, "Ticlopidine-Induced Cholestatic Hepatitis," Ann Pharmacother, 2003, 37(3):371-5. Tilidine CAS Number 20380-58-9; 2107-79-5; 24357-97-9 Impairment Potential Yes Unlabeled/Investigational Use" ...
More about this bookBuprenorphine: Combatting Drug Abuse with A Unique Opioid
by Alan Cowan and John W. Lewis (Hardcover - Jan 15, 1995)
Excerpt:
... "tilidine and different doses of codeine. Psychopharmacology 94:315-320. Hoffmeister F, Schlichting" ...
More about this bookHistopathology of Preclinical Toxicity Studies, Third Edition: Interpretation and Relevance in Drug Safety Evaluation
by Peter Greaves (Hardcover - April 6, 2007)
More about this book
medicine: tilidine
tilidine description
Tilidine (INN, USAN), or tilidate (BAN) (Valoron, Valtran, Tilidin) is a synthetic opioid analgesic, used mainly in Germany and Switzerland for treatment of moderate to severe pain, both acute and chronic. Considered a low- to medium-potency opioid, it has the oral potency of about 0.2, i.e., a dose of 100 mg p.o. is equianalgesic to approximately 20 mg morphine sulfate orally. It is administered orally (by mouth), rectally (by a suppository), or by injection (s.c., i.m. or slowly i.v.) with single doses of 50 to 100 mg, the maximal daily dose being up to 600 mg.
Tilidine itself is only a weak opioid, but is rapidly metabolised in the liver and gut to its active metabolites nortilidine and bisnortilidine, which are fairly potent, µ-selective agonists. It is manufactured by a Diels-Alder reaction of 1-N,N-dimethylaminobuta-1,3-diene with ethyl atropate, yielding a mixture of isomers, of which only the (E)-(trans)-isomers are active and is separated subsequently from the mixture by precipitation of the inactive (Z)-(cis)-isomers as zinc complex.
Tilidine is used in the form of hydrochloride or phosphate salt. In Germany, tilidine is available in a fixed combination with naloxone for oral administration (Valoron N and generics); the admixture of naloxone is claimed to lower the abuse liability of the opioid analgesic. In Switzerland the original Valoron brand with only tilidine and no naloxone is also available.
As well as its use as an analgesic, tilidine is also commonly used in Germany for treatment of restless legs syndrome.
Notes
^ Martindale: The Complete Drug Reference^ Waldvogel: Analgetika, Antinozizeptiva, Adjuvanzien. (in german)
^ Buschmann: Analgesics.
^ Schulz R, Bläsig J, Wüster M, Herz A. The opiate-like action of tilidine is mediated by metabolites. Naunyn Schmiedebergs Archives of Pharmacology. 1978 Sep 12;304(2):89-93.
^ Robert M. Novack. Process for producing substituted cyclohexene compounds. US Patent 3649628
^ Fachinfo (SPC) for Valoron N (in german)
^ Tings T, Trenkwalder C. When L-Dopa preparations, dopamine agonists or opioids? Therapy of restless legs syndrome. (German) MMW Fortschritte der Medizin. 2003 Mar 6;145(10):48-9. PMID 12688028
v • d • eOpioids (N02A)Opium and
Poppy straw
derivativesCrude opiate
extracts
Compote/Kompot/Polish heroin · Diascordium · B & O Supprettes · Dover's powder · Laudanum · Mithridate · Opium · Paregoric · Poppy straw concentrate · Poppy tea · Smoking Opium · Theriac
Natural OpiatesOpium Alkaloidssee also: Components of Opium
Codeine · Morphine · Oripavine · Pseudomorphine · Thebaine
Alkaloid Salts MixturesPantopon · Papaveretum (Omnopon) · Tetrapon
SemisyntheticsMorphine Family14-Hydroxymorphine · 14β-Hydroxymorphine · 14β-Hydroxymorphone · 2,4-Dinitrophenylmorphine · 6-Methyldihydromorphine · 6-Methylenedihydrodesoxymorphine · 6-Acetyldihydromorphine/6-Monoacetyldihydromorphine · Acetyldihydromorphine · Azidomorphine · Chlornaltrexamine · Chloromorphide · Dihydrodesoxymorphine (Desomorphine) · Dihydromorphine · Ethyldihydromorphine · Hydromorphinol · Methyldesorphine · N-Phenethylnormorphine · Pseudomorphine
3,6 Diesters of MorphineDiacetyldihydromorphine (Dihydroheroin) · Dibenzoylmorphine · Dibutanoylmorphine · Dipropanoylmorphine · Disalicyloylmorphine · heroin (Diacetylmorphine) · Heroin-7,8-Oxide · Nicomorphine
Codeine-Dionine Family14-Hydroxydihydrocodeine · Acetylcodeine · Benzylmorphine · codeine methylbromide · Desocodeine · methyldihydromorphine (Dihydroheterocodeine) · Ethylmorphine (Dionine) · Heterocodeine · Isocodeine · Morpholinylethylmorphine (Pholcodine) · Myrophine · Nalodeine · Transisocodeine
Morphinones14-Ethoxymetopon · 14-Methoxymetopon · 14β-Hydroxymorphone · 14-O-Methyloxymorphone · 14-Phenylpropoxymetopon · 7-Spiroindanyloxymorphone · 8,14-Dihydroxydihydromorphinone · Acetylmorphone · Ethyldihydromorphinone · Hydromorphinone · Hydromorphone · Hydroxycodeine · Methyldihydromorphinone · Metopon · Morphinol · Morphinone · N-Phenethyl-14-ethoxymetopon · Oxymorphol · Oxymorphone · Pentamorphone · Semorphone
Codeinones1-carboxy-14-hydroxydihydrocodeinone · 1-carbethoxy-14-hydroxydihydrocodeinone · thebacon (Acetyldihydrocodeinone / Dihydrocodeinone enol acetate) · Codeinone · Codorphone · Codoxime · Hydrocodone · Monodihydrocodeineone · Oxycodone
Dihydrocodeine Series14-hydroxydihydrocodeine · Acetyldihydrocodeine · Dihydrocodeine · Dihydrodesoxycodeine/Desocodeine · Dihydroisocodeine · Nicocodeine · Nicodicodeine
Nitrogen morphine DerivativesCodeine-N-Oxide · Heroin-N-Oxide · Hydromorphone-N-Oxide · Morphine-N-Oxide
HydrazonesHydromorphazone · Morphazone · Oxymorphazone
Othersα-chlorocodide · Pholcodine
Active OpiateMetabolites
Codeine-N-Oxide (Genocodeine) · Dihydromorphine-6-glucuronide · Hydromorphone-N-Oxide · Heroin-7,8-Oxide · Morphine-6-glucuronide · 6-Acetylmorphine · Morphine-N-Oxide (Genomorphine) · Naltrexol · Norcodeine · Normorphine
MorphinansMorphinan Series4-chlorophenylpyridomorphinan · Cyclorphan · Dextro-3-hydroxy-N-allylmorphinan · Dimemorfan · Levargorphan · Levallorphan · Levorphanol · Levorphan · Levophenacylmorphan · Levomethorphan · Norlevorphanol · N-Methylmorphinan · Oxilorphan · Phenomorphan · methorphan / Racemethorphan · morphanol / Racemorphanol · Ro4-1539 · Stephodeline · Xorphanol
Others1-Nitroaknadinine · 14-episinomenine · 5,6-Dihydronorsalutaridine · 6-Ketonalbuphine · Aknadinine · Butorphanol · Cephakicine · Cephasamine · Cyprodime · Drotebanol · Fenfangjine G · Nalbuphine · Sinococuline · Sinomenine (Cocculine) · Tannagine
Benzomorphans5,9-DEHB · Alazocine · Anazocine · Bremazocine · Cogazocine · Cyclazocine · Dezocine · Eptazocine · Etazocine · Ethylketocyclazocine · Fluorophen · Ketazocine · Metazocine · Pentazocine · Phenazocine · Quadazocine · Thiazocine · Tonazocine · Volazocine · Zenazocine
4-PhenylpiperidinesPethidines(Meperidines)
Allylnorpethidine · Anileridine · Benzethidine · Carperidine · Difenoxin · Diphenoxylate · Etoxeridine (Carbetidine) · Furethidine · Hydroxypethidine (Bemidone) · Hydroxymethoxypethidine · Morpheridine · Oxpheneridine (Carbamethidine) · Meperidine-N-Oxide · Pethidine (Meperidine) · pethidine Intermediate A · pethidine Intermediate B (Norpethidine) · pethidine Intermediate C (Pethidinic Acid) · Pheneridine · Phenoperidine · Piminodine · Properidine (Ipropethidine) · Sameridine
ProdinesAllylprodine · Isopromedol · meprodine (α-meprodine / β-meprodine) · MPPP (Desmethylprodine) · PEPAP · prodine (α-prodine / β-prodine) · Prosidol · Trimeperidine (Promedol)
KetobemidonesAcetoxyketobemidone · Droxypropine · Ketobemidone · Methylketobemidone · Propylketobemidone
OthersAlvimopan · Loperamide · PicenadolOpen ChainOpioidsAmidones
Dextromethadone · Dextroisomethadone · Dipipanone · Hexalgon (Norpipanone) · Isomethadone · Levoisomethadone · Levomethadone · Methadone · methadone intermediate · Normethadone · Norpipanone · phenadoxone (Heptazone) · Pipidone
MethadolsDimepheptanol (Racemethadol) · Levacetylmethadol · Noracetylmethadol
MoramidesDextromoramide · Levomoramide · Moramide intermediate · Racemoramide
ThiambutenesDiethylthiambutene · Dimethylthiambutene · Ethylmethylthiambutene · Piperidylthiambutene · Pyrrolidinylthiambutene · Thiambutene · Tipepidine
PhenalkoxamsDextropropoxyphene (Propoxyphene) · Dimenoxadol · Dioxaphetyl Butyrate · Levopropoxyphene · Norpropoxyphene
AmpromidesDiampromide · Phenampromide · Propiram
OthersIC-26 · Isoaminile · Lefetamine · R-4066
Anilidopiperidines3-Allylfentanyl · 3-Methylfentanyl · 3-Methylthiofentanyl · Alfentanil · α-methylacetylfentanyl · α-methylfentanyl · α-methylthiofentanyl · Benzylfentanyl · β-hydroxyfentanyl · β-hydroxythiofentanyl · β-methylfentanyl · Brifentanil · Carfentanil · Fentanyl · Lofentanil · Mirfentanil · Ocfentanil · Ohmefentanyl · Parafluorofentanyl · Phenaridine · Remifentanil · Sufentanil · Thenylfentanyl · Thiofentanyl · Trefentanil
Oripavinederivatives
6,14-Endoethenotetrahydrooripavine · 7-PET · Acetorphine · Alletorphine · BU-48 · Buprenorphine · Butorphine · Cyprenorphine · Dihydroetorphine · diprenorphine (M5050) · Etorphine · 18,19-Dehydrobuprenorphine (HS-599) · N-cyclopropylmethyl-noretorphine · Nepenthone · Norbuprenorphine · Thevinone · Thienorphine
PhenazepinesEthoheptazine · Meptazinol · Metheptazine · Metethoheptazine · Proheptazine
PirinitramidesBezitramide · Piritramide
BenzimidazolesClonitazene · Etonitazene · Nitazene
Indoles18-MC · 7-Acetoxymitragynine · 7-Hydroxymitragynine · Akuammidine · Akuammine · Eseroline · Hodgkinsine · Ibogaine · Mitragynine · Noribogaine · Pericine · ψ-Akuammigine
DiphenylmethylpiperazinesBW373U86 · DPI-221 · DPI-287 · DPI-3290 · SNC-80
Opioid peptidessee also: The Opioid Peptides
Casomorphin · DADLE · DALDA · DAMGO · Dermenkephalin · Dermorphin · Deltorphin · DPDPE · Dynorphin · Endomorphin · Endorphin · Enkephalin · Gliadorphin · Morphiceptin · Nociceptin · Octreotide · Opiorphin · Rubiscolin · TRIMU 5
Others3-(3-Methoxyphenyl)-3-ethoxycarbonyltropane · Azaprocin · BDPC · Bisnortilidine · BRL-52537 · C-8813 · Ciramadol · Enadoline · Faxeladol · Herkinorin · J-113,397 · JTC-801 · Methopholine · NNC 63-0532 · Nortilidine · O-Desmethyltramadol · Phenadone · Prodilidine · Profadol · Ro64-6198 · Salvinorin A · SB-612,111 · SC-17599 · RWJ-394,674 · TAN-67 · Tapentadol · Tecodine · Tifluadom · Tilidine · Tramadol · Trimebutine · Viminol · W-18 ·
Opioid Antagonists&
Inverse-Agonists
5'-Guanidinonaltrindole · β-Funaltrexamine · 6β-Naltrexol · Alvimopan · Amiphenazole · Binaltorphimine · Chlornaltrexamine · Clocinnamox · Cyclazocine · Cyprodime · diprenorphine (M5050) · Fedotozine · JDTic · Levallorphan · Methocinnamox · Methylnaltrexone · Nalfurafine · Nalmefene · Nalmexone · Naloxazone · Naloxonazine · Naloxone · naloxone benzoylhydrazone · Nalorphine · Naltrexone · Naltriben · Naltrindole · Norbinaltorphimine · Oxilorphan · S-allyl-3-hydroxy-17-thioniamorphinan (SAHTM)
This analgesic-related article is a stub. You can help Wikipedia by expanding it.v • d • eRetrieved from "http:en.boinc.org/boinc/Tilidine"Categories: Opioids | Analgesics | Acetates | Analgesic stubsTags
Keywords related to tilidine
tirofiban pirprofen niaprazine ephedrine racemethorphan actarit falecalcitriol dithranol colestyramine pegvisomant ancrod spectazole peridex vinconate cozaar amcill hexal diclac tequin oxetacaine rapacuronium hexamethonium inapsine dimercaprol oxyphenonium bromide arimidex amitriptyline alglucerase cyclizine levopropylhexedrine risperidone duteplase morpheridine atipamezole orapred vitaped calmurid tiocarlide florinef celebrex anastrozole depocyt dosulepin paromomycin sulfate pirlimycin duricef technetium 99mtc arcitumomab potassium canrenoate phendimetrazine polyglycolide ertaczo acebutolol hcl moroxydine fortamet cetrimonium bromide caffeine citrate benznidazole elestat septisol hexamethonium bromide