medicine: tenocyclidine

tenocyclidine description








Tenocyclidine (TCP) is a dissociative anesthetic drug with stimulant and hallucinogenic effects. It is similar in effects to phencyclidine (PCP) but is considerably more potent. TCP has slightly different binding properties to PCP, with more affinity for the NMDA receptors, but less affinity for the sigma receptors. Because of its high affinity for the PCP site of the NMDA receptor complex, the H radiolabelled form of TCP is widely used in research into NMDA receptors.

TCP acts primarily as an NMDA receptor antagonist which blocks the activity of the NMDA receptor, however its increased stimulant effects compared to PCP suggests it also has relatively greater activity as a dopamine reuptake inhibitor (DRI). Due to its similarity in effects to PCP, TCP was placed into the Schedule I list of illegal drugs in the 1970s, although it was only briefly abused in the 1970s and 1980s and is now little known.

See also

Arylcyclohexylamine

Tags

Keywords related to tenocyclidine

nevirapine levo dromoran indahexal dextroamphetamine docusate emend votumumab pheneticillin benzbromarone tioguanine motretinide acular mafosfamide calcium saccharate thiamazole benzalkonium chloride bithionol buserelin ciclonicate oxycinchophen alavert solage ciclosporin sufenta phenergan rivastigmine cordarone pentoxyverine viloxazine depodur ranelic acid figitumumab oxyphenisatine toloxatone phetharbital rosoxacin dibekacin zaleplon nimotuzumab interferon gamma hycomine propranolol stimate metildigoxin mepacrine cefodizime dimetacrine ephedrine colfosceril palmitate eryped libritabs fosphenytoin penlac mecrilate


  • Related news