medicine: plendil

plendil description

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Felodipine is a calcium channel blocker (calcium antagonist), a drug used to control hypertension (high blood pressure). It is marketed under the brand name Plendil by AstraZeneca and Renedil by Sanofi-Aventis. The formulation patent for the substance expired in 2007.

AstraZeneca dropped Plendil from its support and AZ&Me free Rx access program in October 2008.

Interactions

Recent findings have suggested that felodipine in combination with grapefruit juice can cause toxic effects. Oral administration of felodipine is first metabolized in the gastrointestinal tract and liver by the enzyme CYP3A4. Grapefruit juice contains bergamottin which is found to have an inhibiting effect over this enzyme and as a result the bioavailability of the drug increases, raising the risk for abnormal side effects.

Trade names

Trade names and prices of plendil

Name Information Price* Quantity
       
Generic Felodipine SR 2.5mg 28 tablets $24 28 tablets
Generic Felodipine SR 5 mg 28 tablets $27 28 tablets
Generic Felodipine SR 10 mg 28 tablets $34 28 tablets
Plendil 2.5mg 100 tablets (felodipine) $81 100 tablets
Plendil 5 mg 100 tablets (felodipine) $96 100 tablets
Plendil 10 mg 100 tablets (felodipine) $119 100 tablets

*) Prices related to some of online drugstores. There are only approximate prices. For some of drugs is needed a prescription.

Tags

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