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medicine: ismo
ismo description
Go to trade names and prices
Isosorbide mononitrate is a drug used principally in the treatment of angina pectoris and acts by dilating the blood vessels so as to reduce the blood pressure. It is sold by AstraZeneca under the trade name Imdur, and marketed in the UK under the trade names: Monosorb, Chemydur. In india this drug is available under the brand names of Sorbitrate, Monotrate, Solotrate, and Monit.
Uses
Isosorbide mononitrate is used for the prophylactic treatment of angina pectoris; that is, it is taken in order to prevent or at least reduce the occurrence of angina. Research on isosorbide mononitrate as a cervical ripener to reduce time at hospital to birth is supportive.
Side effects
The adverse reactions which follow have been reported in studies with isosorbide mononitrate:
Very common: Headache predominates (up to 30%) necessitating withdrawal of 2 to 3 % of patients, but the incidence reduces rapidly as treatment continues .
Common: Tiredness, sleep disturbances (6%) and gastrointestinal disturbances (6%) have been reported during clinical trials with isosorbide mononitrate modified release tablets, but at a frequency no greater than for placebo. Hypotension (4 to 5%), poor appetite (2.5%), nausea (1%).
Adverse effects associated with the clinical use of the drug are as expected with all nitrate preparations. They occur mainly in the early stages of treatment.
Hypotension (4%) with symptoms such as dizziness and nausea (1%) have been reported. These symptoms generally disappear during long-term treatment.
Other reactions that have been reported with isosorbide mononitrate modified release tablets include tachycardia, vomiting, diarrhoea, vertigo and heartburn.
Interactions
Sildenafil (Viagra). Concomitant administration of isosorbide mononitrate and sildenafil (Viagra) can potentiate the vasodilatory effect of isosorbide mononitrate with the potential result of serious side effects such as syncope or myocardial infarction. Therefore, sildenafil should not be given to patients already receiving isosorbide mononitrate therapy.Sulfhydryl containing compounds. The metabolism of organic nitrates to nitric oxide is dependent on the presence of sulfhydryl groups in the muscle. The combination of oral N-acetylcysteine and a single dose of sustained release isosorbide mononitrate 60 mg significantly prolonged the total exercise time in patients with angina pectoris and angiographically proven significant coronary artery disease, when compared with isosorbide mononitrate alone. Concomitant administration of other exogenous sources of sulfhydryl groups such as methionine and captopril may produce a similar interaction.
Phenylalkylamine calcium antagonists. The addition of a calcium channel blocker of the verapamil type, such as gallopamil 75 mg, has been shown to further improve left ventricular functional parameters when given in combination with isosorbide mononitrate in a sustained release formulation.
Propranolol. The addition of isosorbide mononitrate to propranolol treatment in patients with cirrhosis and portal hypertension caused a marked fall in portal pressure, a reduction in hepatic blood flow, cardiac output and mean arterial blood pressure, but no additional change in azygos blood flow. The additional effect of isosorbide mononitrate was especially evident in patients whose portal pressure was not reduced by propranolol.
Calcium antagonists (general). Marked symptomatic orthostatic hypotension has been reported when calcium antagonists and organic nitrates were used in combination. Dose adjustments of either class of agent may be necessary.
| Name | Information | Price* | Quantity |
| Generic Bismuth | 30 tablet (Bismuth Subsalicylate, Calcium Carbonate) | $6 | 30 tablet |
| Generic Bismuth Liquid Max Strength | 237 ml (bismuth subsalicylate) | $6 | 237 ml |
| Ismo 10mg | 60 tablet (isosorbide mononitrate) | $13 | 60 tablet |
| Ismo 20mg | (isosorbide mononitrate) | N/A | |
| Ismo 40mg | 60 tablet (isosorbide mononitrate) | $28 | 60 tablet |
| Generic Isosorbide Mononitrate 10mg | 60 tablets | $14 | 60 tablets |
| Generic Isosorbide Mononitrate 20mg | 56 tablets | $11 | 56 tablets |
| Generic Isosorbide Mononitrate 40mg | 56 tablets | $21 | 56 tablets |
| Generic Peptic Relief 262mg/15mL | 473 ml | $7 | 473 ml |
| Pepto Bismol Chew Tab 24tab | 24 tablet (Bismuth Subsalicylate, Calcium Carbonate) | $8 | 24 tablet |
| Pepto Bismol Chewables Cherry 262mg | 48 tablet (Bismuth Subsalicylate) | $7 | 48 tablet |
| Pepto Bismol Chewables Original 262mg | 48 tablet (Bismuth Subsalicylate) | $7 | 48 tablet |
| Pepto Bismol Childrens Chewables Bubblegum 400mg | 24 tablet (Calcium Carbonate) | $8 | 24 tablet |
| Pepto Bismol Childrens Chewables Watermelon 400mg | 24 tablet | $8 | 24 tablet |
| Pepto Bismol Easy To Swallow Caplets 262mg | 40 caplet (Bismuth Subsalicylate) | $7 | 40 caplet |
| Pepto Bismol Liquid 17.6mg/ml | 480 ml (bismuth subsalicylate) | $15 | 480 ml |
| Pepto Bismol Liquid Cherry 17.6mg/ml | 480 ml (bismuth subsalicylate) | $15 | 480 ml |
| Pepto Bismol Liquid Cherry 262mg/15ml | 227 ml (Bismuth Subsalicylate) | $7 | 227 ml |
| Pepto Bismol Liquid Maximum Strength 525mg/15ml | 354 ml (Bismuth Subsalicylate) | $14 | 354 ml |
| Pepto-Bismol Maximum Strength Liquid | 240 ml (Bismuth Subsalicylate) | $10 | 240 ml |
*) Prices related to some of online drugstores. There are only approximate prices. For some of drugs is needed a prescription.
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