medicine: iopanoic acid
iopanoic acid description
Iopanoic acid is a molecule used as a contrast medium.
Iopanoic acid and ipodate are iodine containing radiocontrast media. They are potent inhibitors of thyroid hormone release from thyroid gland, as well as of peripheral conversion of T4(thyroxine) to T3(triiodothyronine). These compounds inhibit 5'deiodinase (5'DID-1 and 5'DID-2) enzymes which catalyse the above conversion (thyroxine to triiodothyronine) in the thyroid cell, liver, kidney, skeletal muscle, heart, brain, pituitary. This accounts for the dramatic improvement in both subjective and objective symptoms of hyperthyroidism particularly when they are used as an adjunctive therapy with thioamides (propylthiouracil, carbimazole). These are less toxic as iodine is covalently bound in these compounds. Used in the treatment of patients with severe thyrotoxicosis (thyroid storm) and significant morbidity (e.g., myocardial infarction, or stroke) for rapid control of elevated plasma triiodothyronine concentrations.
v • d • eContrast media (V08)X-rayIodinated,Water-solubleNephrotropic,
high osmolarDiatrizoic acid · Metrizoic acid · Iodamide · Iotalamic acid · Ioxitalamic acid · Ioglicic acid · Acetrizoic acid · Iocarmic acid · Methiodal · DiodoneNephrotropic,
low osmolarMetrizamide · Iohexol · Ioxaglic acid · Iopamidol · Iopromide · Iotrolan · Ioversol · Iopentol · Iodixanol · Iomeprol · Iobitridol · IoxilanHepatotropicIodoxamic acid · Iotroxic acid · Ioglycamic acid · Adipiodone · Iobenzamic acid · Iopanoic acid · Iocetamic acid · Sodium iopodate · Tyropanoic acid · Calcium iopodateIodinated,
Non-water-solubleEthyl esters of iodised fatty acids · Iopydol · Propyliodone · Iofendylate · LipiodolNon-iodinatedBarium sulfateMRIParamagneticGadopentetic acid · Gadoteric acid · Gadodiamide · Gadolinium · Gadoteridol · Mangafodipir · Gadoversetamide · Ferric ammonium citrate · Gadobenic acid · Gadobutrol · Gadoxetic acidSuperparamagneticFerumoxsil · Ferristene · Iron oxide, nanoparticlesOtherPerflubronUltrasoundMicrospheres of human albumin · Microparticles of galactose · Perflenapent · Microspheres of phospholipids · Sulfur hexafluorideWHO-EM. Withdrawn from market. CLINICAL TRIALS: Phase III. Never to phase IIIRetrieved from "http:en.boinc.org/boinc/Iopanoic_acid"Categories: Pharmacology stubs | Radiocontrast agents | Organoiodides
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