-
Related books
The Parkinson's Disease Treatment Book: Partnering with Your Doctor to Get the Most from Your Medications
by J. Eric Ahlskog M.D. Ph.D. (Hardcover - Aug 1, 2005)
Excerpt:
... "Inhibitors Two COMT inhibitors are available as treatment for PD, entacapone (Comtan) and tolcapone (Tasmar)." ...
More about this bookParkinson's Disease Treatment Guide for Physicians
by J. Eric Ahlskog MD PhD (Hardcover - Mar 25, 2009)
Excerpt:
... "the benefits are significant, but not dramatic, and comparable to entacapone.48,49 rasagiline may be administered as a single 0.5 or I.0" ...
More about this bookParkinson's Disease: A Complete Guide for Patients and Families, Second Edition (A Johns Hopkins Press Health Book)
by William J. Weiner MD, Lisa M. Shulman MD, and Anthony E. Lang MD FRCP (Paperback - Nov 13, 2006)
Excerpt:
... "Moderate Parkinson's Disease 53 entacapone (Comtan), which do sometimes cause diarrhea; in its se- vere" ...
More about this bookHandbook of Parkinson's Disease, Fourth Edition (Neurological Disease and Therapy)
by Rajesh Pahwa and Kelly E. Lyons (Hardcover - Mar 23, 2007)
Excerpt:
... "by combining levodopa with a catechol O-methyl-transferase inhibitor such as entacapone or tolcapone, or using a night- time dose of a" ...
More about this bookParkinson's Disease: A Guide to Patient Care
by Dr. Paul Tuite MD, Cathi Thomas RN MS, Dr. Laura Ruekert PharmD RPh, and Dr. Hubert Fernandez MD (Paperback - Mar 23, 2009)
Excerpt:
... "frequency of dosing, or adding a "levodopa extender" such as entacapone." ...
More about this bookParkinsonian Disorders in Clinical Practice
by Anthony Schapira, Andreas Hartmann, and Yves Agid (Paperback - Jun 2, 2009)
Excerpt:
... "Treatment of Parkinson's disease 43 2.5 Levodopa/DDCI and entacapone 2 O 2.0 ~ 3 ~ 1.5 ~" ...
More about this bookHandbook of Parkinson's Disease (Neurological Disease and Therapy)
by Rajesh Pahwa, Kelly E. Lyons, and William Koller (Hardcover - Mar 25, 2003)
Excerpt:
... "in parkinson's disease 377 compounds, eventually bearing the names nitecapone, entacapone, and tolcapone, became the favored subjects of laboratory, and eventually" ...
More about this bookParkinson's Disease: Questions and Answers, Fourth Edition
by Robert Hauser, Kelly Lyons, Rajesh Pahwa, and Theresa Zesiewicz (Paperback - Jul 2003)
Excerpt:
... "When levodopa is administered with entacapone, a COMT inhibitor that prolongs the levoclopa half-life, the development" ...
More about this bookParkinson's Disease
by Peter Lewitt (Hardcover - May 30, 1999)
Excerpt:
... "The two COMT inhibitors entacapone and tolcapone will now be discussed. Entacapone Entacapone has been" ...
More about this bookParkinson Disease Guidelines Pocketcard: American Academy of Neurology ( 2008 )
by American Academy Of Neurology and International Guidelines Center (Pamphlet - Jul 9, 2009)
Excerpt:
... "carbidopa/levidopa (without entacapone2 37.5/150/200 mg tablets carbidpoa/levidopa above (only one entacapone) therapy if patient experiences end-of-dose "wearing off" Stalevo tablet per" ...
More about this bookNeurological Drug Reactions and Interactions
by Jerome Z. Litt (Paperback - Nov 3, 2005)
Excerpt:
... "rapacuronium Reactions Skin Shivering ENTACAPONE Other Rhabdomyolysis [I] Seizures [I] Trade name:" ...
More about this bookEntacapone blunts cravings in marijuana users.(ADDICITION PSYCHIATRY): An article from: Clinical Psychiatry News
by Fran Lowry (Digital - April 8, 2009) - HTML
More about this book
medicine: entacapone
entacapone description
Go to trade names and prices
Entacapone (INN) (pronounced /ˌɛntəkəˈpoʊn/, /ɛnˈtækəpoʊn/) is a drug that functions as a catechol-O-methyl transferase (COMT) inhibitor. It is used in the treatment of Parkinson's disease.
When administered in conjunction with dopaminergic agents such as L-DOPA, entacapone prevents COMT from metabolizing L-DOPA into 3-methoxy-4-hydroxy-L-phenylalanine (3-OMD) in the periphery, which does not easily cross the blood brain barrier (BBB). Pharmacologically, entacapone is somewhat similar to carbidopa or benserazide, in that it is an inhibitor of an enzyme that converts L-DOPA into a compound that cannot cross the BBB. carbidopa and beserazide inhibit aromatic L-amino acid decarboxylase, which converts L-DOPA into dopamine, which cannot cross the BBB.
Entacapone is a member of the class of drugs known as nitrocatechols.
The most frequent undesirable effects caused by entacapone relate to the increased effects of L-DOPA, such as involuntary movements (dyskinesias). These occur most frequently at the beginning of entacapone treatment. Others common side effects are gastrointestinal problems, including diarrhoea, nausea and abdominal pains. The substance may cause urine to turn reddish-brown. This is a harmless side effect and is not a cause for concern. In studies with entacapone, some people have reported experiencing a dry mouth.
Products
Entacapone is developed by Orion Pharma and marketed by Novartis under the trade name comtan in the United States.
Stalevo is another Novartis medication that contains entacapone in combination with carbidopa and levodopa (active ingredients in Sinemet).
| Name | Information | Price* | Quantity |
| Generic Carbidopa/Entacapone/Levodopa 12.5mg/200mg/50mg | 50 tablet | $70 | 50 tablet |
| Generic Carbidopa/Entacapone/Levodopa 25mg/200mg/100mg | 50 tablet | $70 | 50 tablet |
| Generic Carbidopa/Entacapone/Levodopa 37.5mg/200mg/150mg | 50 tablet | $78 | 50 tablet |
| Comtan 200mg | 100 tablets (entacapone) | $140 | 100 tablets |
| Generic Entacapone 200mg | 50 tablet | $55 | 50 tablet |
| Stalevo 12.5mg/200mg/50mg | 100 tablets (carbidopa/entacapone/levodopa) | $179 | 100 tablets |
| Stalevo 100 25mg/200mg/100mg | 100 tablets (carbidopa/entacapone/levodopa) | $179 | 100 tablets |
| Stalevo 125 31.25mg/200mg/125mg | 100 tablets (carbidopa/entacapone/levodopa) | $179 | 100 tablets |
| Stalevo 150 37.5mg/200mg/150mg | 100 tablets (carbidopa/entacapone/levodopa) | $200 | 100 tablets |
| Stalevo 200 200mg/50mg/200mg | 100 tablet (carbidopa, entacapone, levodopa) | $237 | 100 tablet |
| Stalevo 75 18.75mg/200mg/75mg | 100 tablets (carbidopa/entacapone/levodopa) | $179 | 100 tablets |
*) Prices related to some of online drugstores. There are only approximate prices. For some of drugs is needed a prescription.
Tags
Keywords related to entacapone
etanercept mivazerol trimetaphan camsilate ximelagatran meclofenamic acid benznidazole lithobid dtpa etrafon fampridine altumomab hexamine dinitolmide tetrahydrobiopterin duvoid carpronium chloride valaciclovir nysert azaprocin darifenacin carboplatin cyclobarbital rufinamide stavudine moexipril levophed diisopromine aldactone hexapropymate batimastat tirapazamine sodium dehydrocholate oseltamivir levodopa insulin glargine cefalexin antizol targretin intal selegiline emedastine chlorphentermine arotinolol calcium channel blocker sabcomeline poloxamer