medicine: dicoumarol

dicoumarol description








Dicoumarol (INN) or dicumarol (USAN) is an anticoagulant that functions as a Vitamin K antagonist (similar to warfarin). It is also used in biochemical experiments as an inhibitor of reductases. Dicoumarol is a chemical substance of plant origin, a derivative of coumarin. It is given only orally, and it acts within two days.


Mechanism of action : it is a competitive inhibitor of Vitamin K preventing the formation of prothrombin. Administration of Vitamin K is the antidote for dicoumarol toxicity. Follow-up is done by measuring the Prothrombin time (PT).

Uses: Used along with heparin for the treatment of deep venous thrombosis

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