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medicine: arimidex
arimidex description
Go to trade names and prices
Anastrozole (INN, trade name Arimidex, AstraZeneca) is a drug used to treat breast cancer after surgery and for metastases in post-menopausal women.
Anastrozole is an aromatase inhibitor, which means that it interrupts a critical step in the body's synthesis of estrogen. Some breast cancer cells require estrogen to grow, and eliminating estrogen suppresses their growth.
Annual sales approx $2.2bn. Patent expires 2010 in the US; however, the generic form is available in some other markets.
Clinical trials
The ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial represents a long-term follow-up study of 9366 women with localized breast cancer who received either anastrozole, tamoxifen, or both. After more than 5 years the group that received anastrozole had significantly better clinical results than the tamoxifen group. The trial suggested that anastrozole is the preferred medical therapy for postmenopausal women with localized breast cancer that is estrogen receptor (ER) positive.
Another study found that the risk of recurrence was reduced 40% (with some risk of bone fracture) and that ER negative patients also benefited from switching to Arimidex.
Mechanism of Action
Anastrozole inhibits the enzyme aromatase, which is responsible for converting androgens to estrogens. anastrozole binds reversibly to the aromatase enzyme through competitive inhibition.
Elevated levels of estrogens may increase the severity of breast cancer, as sex hormones can cause hyperplasia and differentiation at estrogen receptor sites.
Side effects
Bone weakness : Women who switched to Arimidex (after two years on tamoxifen) reported twice as many fractures as those who continued to take tamoxifen (2.1% compared to 1%).
Bisphosphonates are sometimes prescribed to prevent the osteoporosis induced by aromatase inhibitors but have another serious side effect, osteonecrosis of the jaws. Since statins have a bone strengthening effect , combining a statin with an aromatase inhibitor may avoid both fractures and possible cardiovascular risks without jaw osteonecrosis. In one study of women with breast cancer taking anastrozole, statin use was associated with a 38% reduced fracture risk, or approximately the equivalent of 10 mg fosamax daily.
Usage for men
While officially indicated for women, this drug has proven effective in the off-label use of reducing estrogens (in particular and more importantly, estradiol) in men. Excess estradiol in men can cause benign prostatic hyperplasia, gynecomastia, and symptoms of hypogonadism. Some athletes and body builders will also use anastrozole as a part of their steroid cycle to reduce and prevent symptoms of excess estrogens; in particular, gynecomastia and water retention.
Study data currently suggests that dosages of 0.5 mg to 1 mg a day reduce serum estradiol by about 50% in men, which differs from the typical reduction in postmenopausal women. However the reduction may be different for men with grossly elevated estradiol (clinical data is currently lacking).
Usage for children
This drug is frequently used in the treatment of children with growth disorder to stop or slow the onset of puberty. The cause of the growth disorder is through hormones which may trigger the early onset of puberty. At the onset of puberty the bone growth plates begin to close. This can occur in children as young as 5 years old, so for children severely behind in growth, the opportunity for increased growth is diminished. Arimidex is shown to slow or stop this process.
| Name | Information | Price* | Quantity |
| Generic Anastrozole 1mg | 30 tablets (Anastrozole) | $142 | 30 tablets |
| Arimidex 1mg | 28 tablets (anastrozole) | $175 | 28 tablets |
*) Prices related to some of online drugstores. There are only approximate prices. For some of drugs is needed a prescription.
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