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Alnespirone (S-20499) is a psychoactive drug and research chemical from the azapirone chemical class that has anxiolytic and antidepressant properties. It acts as a high-affinity 5-HT1A receptor full agonist. Unlike some of the other azapirone derivatives such as buspirone, alnespirone is fully selective for the 5-HT1A receptor and has negligible affinity for the D2 or α2-adrenergic receptor.

See also

Azapirone

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